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KMID : 1134220080280040030
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Hanyang Medical Reviews
2008 Volume.28 No. 4 p.30 ~ p.31
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Anethesia and Glutamate Receptors
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Do Sang-Hwan
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Abstract
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Glutamate receptors represent major excitatory neurotransmission. Besides anesthesia, pain, memory and learning and neurotoxicity (excitotoxicity) are closely associated with the glutamate receptor, especially the NMDA receptor. Ketamine, an NMDA receptor antagonist, has been highlighted not only as an intravenous anesthetic, but also as a versatile analgesic adjunct. Pharmacologic knowledge on glutamate neurotransmission should help us in improving management
of patients in terms of analgesia, amnesia and neuroprotection.
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KEYWORD
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analgesia, glutamate, ketamine, neuroprotection, NMDA receptor
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